Diabeticnephropathymechanism

The mechanism of action of this drug is to the sodium-glucose uptake cotransporter in the proximal tubule, thereby generating naturesis and glucosuria. In ...

由 S Giunti 著作 · 2006 · 被引用 213 次 — Clinical hallmarks of diabetic nephropathy include a progressive increase in urinary albumin excretion and a decline in glomerular filtration rate (GFR), which ...

由 C Zoja 著作 · 2020 · 被引用 51 次 — Sirtuin-3 is downregulated in the diabetic kidney. Reduced expression in podocytes and glomerular endothelial cells impairs SOD2 antioxidant ...

Pathophysiology is complex, involving glycosylation of proteins, hormonally influenced cytokine release (eg, transforming growth factor-beta), deposition of ...

由 K Reidy 著作 · 2014 · 被引用 846 次 — DKD originates from metabolic dysregulation. The dysregulated metabolic milieu (including hyperglycemia, hyperlipidemia, and insulin resistance) ...

由 Z Cao 著作 · 2011 · 被引用 242 次 — The pathogenesis and progression of diabetic nephropathy are likely to be as a result of interactions between metabolic and hemodynamic pathways ...

由 R Agarwal 著作 · 2021 · 被引用 15 次 — Diabetic nephropathy is classified histologically by the appearance of the glomerulus on kidney biopsy. It progresses from GBM thickening, to mesangial ...

由 V Vallon 著作 · 2011 · 被引用 278 次 — In the kidney, this phenomenon is manifested by expansion of mesangial ECM (580), one of the hallmarks of diabetic nephropathy. In the vascular system, the ...